欧宝娱乐尤文图斯官方合作伙伴施普林格自然RSS提要 //www.veemusicshop.com/ Figshare机构施普林格Nature的RSS提要欧宝娱乐尤文图斯官方合作伙伴 eyJhbGciOiJIUzUxMiJ9.eyJ2YWx1ZXMiOlsxNjY5Mzc5MTM4MDAwLDIxNjIyOTMyXX0.wrD8fN08J5z3qNZM3QvsdNT8NA5759rKMpUNaJtOSlUgxqgWXWfuK74mDDpAiR3zMzeRzhK8z7wSbTg0koEBPQ <![CDATA[基于药理活性、吸收成分和硅内分子对接,确定白头马汤对溃疡性结肠炎治疗靶点的潜在免疫调节剂]> . //www.veemusicshop.com/collections/Identification_of_potential_immunomodulators_from_Pulsatilla_decoction_that_act_on_therapeutic_targets_for_ulcerative_colitis_based_on_pharmacological_activity_absorbed_ingredients_and_in-silico_molecular_docking/6318375//www.veemusicshop.com/collections/Identification_of_potential_immunomodulators_from_Pulsatilla_decoction_that_act_on_therapeutic_targets_for_ulcerative_colitis_based_on_pharmacological_activity_absorbed_ingredients_and_in-silico_molecular_docking/6318375 白头翁汤是治疗溃疡性结肠炎(UC)的经典中药方剂。但是,其有效成分和基本作用机制尚不清楚。在目前的研究中,我们旨在从BTWT中识别潜在的免疫调节剂,作用于UC的治疗靶点。方法采用右旋糖酐硫酸钠所致小鼠结肠炎实验,观察白藜芦醇颗粒的保护作用。利用LC-MS对BTWT吸收的成分进行鉴定,并利用分子对接法对这些成分在UC中的蛋白靶点进行筛选。结果BTWT颗粒口服可明显减轻慢性结肠炎小鼠的疾病严重程度和结肠缩短,抑制炎症反应。在这些小鼠中,在血清和/或结肠中检测到BTWT颗粒中的11种化合物。分子对接研究表明,白头翁中的挥发油苷A3等化合物可与STAT3和S1PR1相互作用;黄连和/或黄柏中的化合物,如巴马汀,与JAK3、PD-1和PD-L1相互作用;秦皮中七叶木苷等成分与S1PR1、JAK3、STAT3、PD-L1互作。 Further in-vitro experiments showing that the compounds inhibited TNF-α and IL-6 production and STAT3 activation in RAW 264.7 cells suggested that these compounds have immunomodulatory activities. Conclusion We revealed for the first time that 11 absorbed ingredients from BTWT were immunomodulators against therapeutic targets for UC. These findings suggest that the identified compounds are the active components of BTWT, and the identified protein targets underlie the mechanism of action of BTWT against UC. 生物化学、医学、细胞生物学、分子生物学、药理学、免疫学、癌症、科学政策、未分类的生物科学、未分类的化学科学、未分类的信息系统 2022年11月26日星期六16:19:57 GMT <![CDATA[欧宝app苹果下载软件基于药理活性、吸收成分和硅内分子对接的白头马汤潜在免疫调节剂对溃疡性结肠炎治疗靶点作用的鉴定附加文件1]> //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Identification_of_potential_immunomodulators_from_Pulsatilla_decoction_that_act_on_therapeutic_targets_for_ulcerative_colitis_based_on_pharmacological_activity_absorbed_ingredients_and_in-silico_molecular_docking/21625401//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Identification_of_potential_immunomodulators_from_Pulsatilla_decoction_that_act_on_therapeutic_targets_for_ulcerative_colitis_based_on_pharmacological_activity_absorbed_ingredients_and_in-silico_molecular_docking/21625401 欧宝app苹果下载软件附加文件1:图S1。M计算结合能构像最低的i)阳性对照配体tofacitinib在JAK3结合位点的分子对接结果,ii) SD-36在STAT3结合位点的分子对接结果,iii) S1P和ML056 (W146)在S1PR1结合位点的分子对接结果(A), iv) ML385在Nrf2结合位点的分子对接结果,nivolumab在PD-1结合位点的分子对接结果,v) BMS-202在PD-L1结合位点的分子对接结果。在二维图像中,蛋白质活性位点的极性残基和非极性残基分别用紫色和绿色表示。侧链和主链中的氢键分别用红色和蓝色线箭头表示;箭头指向h受体。π-H相互作用用红线和芳烃- h标记。金属接触相互作用用紫色线表示。在3D图像中,化合物的碳原子显示为黄色,其他原子(如氧、氮和硫原子)显示为蓝色。与化合物相互作用的蛋白质的氨基酸残基显示为绿色。氢键的形成、π- h相互作用和π-π相互作用用红色虚线表示。 Fig. S2. The effects of 11 components of BTWT on cell viability of splenocytes assessed by MTT assay after 24 h treatment (n = 3). 生物化学、医学、细胞生物学、分子生物学、药理学、免疫学、癌症、科学政策、未分类的生物科学、未分类的化学科学、未分类的信息系统 2022年11月26日星期六16:19:56 GMT <![CDATA[在乌克兰东北部哈尔科夫州收集到的与蝙蝠体外寄生虫有关的细菌的首个数据]> //www.veemusicshop.com/collections/First_data_on_bacteria_associated_with_bat_ectoparasites_collected_in_Kharkiv_oblast_Northeastern_Ukraine/6318373//www.veemusicshop.com/collections/First_data_on_bacteria_associated_with_bat_ectoparasites_collected_in_Kharkiv_oblast_Northeastern_Ukraine/6318373 蝙蝠(哺乳纲:手翅目)是世界上许多人畜共患病病原体的天然宿主,包括病媒传播的病原体。然而,迄今为止,在全球许多地区,蝙蝠相关的寄生节肢动物及其菌群尚未得到全面描述,它们在病原体向其他脊椎动物物种溢出中的作用也尚未得到充分了解。需要进行基础的流行病学研究,以解开蝙蝠之间复杂的生态相互作用、它们所携带的特定体外寄生虫和微生物。一些国家,如乌克兰,在这方面的数据尤其缺乏,因为那里对外寄生动物群的记录很少,而且从未筛查过具有重要医学意义的微生物的存在。因此,本研究的目的是提供这一主题的第一个数据。方法采集蝙蝠节肢动物标本239例。它们属于几个主要的外部寄生虫类群,包括乌克兰东北部六种翼虫科的软蜱、跳蚤和蜱虫。用常规pcr技术分别筛选体外寄生虫中立克次体、无形体/埃利希体、巴尔通体、博氏体和巴贝斯体的DNA。阳性样本在几个位点进行扩增,测序进行物种鉴定,并进行系统发育分析。结果43例软蜱标本中7例(16.3%)检出立克次体DNA。 Sequencing and phylogenetic analysis revealed high similarity to sequences from Rickettsia parkeri and several other Rickettsia species. Bacteria from the family Anaplasmataceae were detected in all groups of the ectoparasites (51%, 122/239 samples), belonging to the genera Anaplasma, Ehrlichia, and Wolbachia. The detection of Bartonella spp. was successful only in fleas (Nycteridopsylla eusarca) and bat flies (Nycteribia koleantii, N. pedicularia), representing 12.1% (29/239) of the collected ectoparasites. No DNA of Babesia or Borrelia species was identified in the samples. Conclusions We report for the first time in Ukraine the molecular detection of several bacterial agents in bat ectoparasites collected from six species of bats. The data presented extend the knowledge on the distribution of ectoparasite species in bats and their involvement in potentially circulating agents pathogenic for humans and vertebrate animals. Graphical Abstract 微生物学 2022年11月26日星期六16:19:54 GMT <![CDATA[欧宝app苹果下载软件在乌克兰东北部哈尔科夫州收集到的与蝙蝠体外寄生虫有关的细菌的第一个数据的附加文件1]> //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_First_data_on_bacteria_associated_with_bat_ectoparasites_collected_in_Kharkiv_oblast_Northeastern_Ukraine/21625399//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_First_data_on_bacteria_associated_with_bat_ectoparasites_collected_in_Kharkiv_oblast_Northeastern_Ukraine/21625399 欧宝app苹果下载软件附加文件1:表S1。为本研究目的而收集的蝙蝠的位置和栖息地点。表S2。用于体外寄生虫病原筛选的引物。表S3。本研究中获得的序列的GenBank登录号。 微生物学 2022年11月26日星期六16:19:54 GMT <![利用RE-AIM框架评估在津巴布韦扩大友谊长凳的实施情况——一项定量观察性研究]> //www.veemusicshop.com/collections/Using_the_RE-AIM_framework_to_evaluate_the_implementation_of_scaling-up_the_Friendship_Bench_in_Zimbabwe_a_quantitative_observational_study/6317376//www.veemusicshop.com/collections/Using_the_RE-AIM_framework_to_evaluate_the_implementation_of_scaling-up_the_Friendship_Bench_in_Zimbabwe_a_quantitative_observational_study/6317376 本研究旨在评估友谊长凳(FB)——一种由社区卫生工作者(CHWs)提供的循证简短心理干预——在津巴布韦三个城市卫生部门实施三年后在现实世界的实施情况。利用RE-AIM框架,根据实施地点的当前表现对其进行了评估,使其成为撒哈拉以南非洲(SSA)大规模循证心理干预的首批评估之一。方法使用RE-AIM指南(www.re-aim.org),作者基于现有FB实施数据设计量化指标。包括哈拉雷(n=28)、Chitungwiza (n=4)和Gweru (n=4)的36个初级保健诊所。在这些诊所中,20个是大型综合保健中心,7个中型(主要是妇幼保健)和9个小型诊所(基本医疗保健和作为转诊诊所)。来自这些诊所的现有数据,加上通过访谈和实地观察收集的额外数据,用于调查和比较FB在各诊所的表现。重点是RE-AIM的覆盖、采用和实现领域。结果小诊所的覆盖率为34%,大诊所为15%,中型诊所为9%。所有临床类型的采用率都很高,从59%到71%不等。小型诊所以53%的比例领先于实施领域,其次是中型诊所43%和大型诊所40%。 Small clinics performed better in all indicators and differences in performance between small and large clinics were significant. Program activity and data quality depends on ongoing support for delivering agents and buy-in from health authorities. Conclusion The Friendship Bench program was implemented over three years transitioning from a research-based implementation program to one led locally. The Reach domain showed the largest gap across clinics where larger clinics performed poorly relative to smaller clinics and should be a target for future implementation improvements. Program data needs to be integrated into existing health information systems. Future studies should seek to optimize scale-up and sustainment strategies to maintain effective task-shared psychological interventions in SSA. 信息系统 2022年11月25日星期五12:40:02 GMT <![使用RE-A欧宝app苹果下载软件IM框架评估扩大津巴布韦友谊长凳项目实施情况的补充文件2 -一项定量观察性研究 //www.veemusicshop.com/articles/journal_contribution/Additional_file_2_of_Using_the_RE-AIM_framework_to_evaluate_the_implementation_of_scaling-up_the_Friendship_Bench_in_Zimbabwe_a_quantitative_observational_study/21622311//www.veemusicshop.com/articles/journal_contribution/Additional_file_2_of_Using_the_RE-AIM_framework_to_evaluate_the_implementation_of_scaling-up_the_Friendship_Bench_in_Zimbabwe_a_quantitative_observational_study/21622311 欧宝app苹果下载软件附加文件2:表2。OPT FB RE-AIM主要研究问卷2019。 信息系统 2022年11月25日星期五12:40:02 GMT <![Er:YAG激光联合氟化治疗对多发性龋患儿龈上菌斑菌群影响的动态研究 //www.veemusicshop.com/collections/The_impact_of_Er_YAG_laser_combined_with_fluoride_treatment_on_the_supragingival_plaque_microbiome_in_children_with_multiple_caries_a_dynamic_study/6317669//www.veemusicshop.com/collections/The_impact_of_Er_YAG_laser_combined_with_fluoride_treatment_on_the_supragingival_plaque_microbiome_in_children_with_multiple_caries_a_dynamic_study/6317669 摘要背景脉冲铒:钇铝石榴石激光器(Er:YAG)作为一种微创防龋工具,正在大量的研究中得到应用。微生物在龋齿的发生和发展中起着极其重要的作用。然而,Er:YAG激光联合氟化物照射对牙菌斑内微生物动态变化的影响尚不明确。在本研究中,我们检测了Er:YAG激光联合氟对多发性龋患儿龈上微生物组成和多样性的影响。方法在本研究中,收集牙菌斑样本(n = 48),来自12名有8颗以上填充牙齿的儿童。收集每位患者氟化治疗前(CB)和氟化治疗后(CA)及氟化+Er:YAG激光治疗前(EB)和氟化+Er:YAG激光治疗后(EA)左下颌磨牙龈上斑块。CB组和EB组在处理前采集样品。CA组和EA组在治疗后1个月采集标本。然后,对所有标本进行16S rRNA高通量测序,研究氟化或氟化+Er:YAG激光治疗前后下颌磨牙龈上斑块微生物组成及多样性的变化。结果EA组牙菌斑微生物多样性高于EB组(基线水平),且与EB组比较,EA组牙菌斑微生物组成发生变化(P < 0.05)。 The levels of microorganisms associated with caries occurrence, including Proteobacteria, Fusobacteria, and Bacteroidetes, declined, while the levels of Faecacterium, Fastidiosipila, Vibrio, and Shewanella increased in EA group compared with EB group. The declines in Firmicutes, Streptococcus, Fusobacterium, and Veillonella levels were significantly lower in the EA group than in the CA group. Conclusion The combined application of the Er:YAG laser and fluoride may be more effective than using fluoride alone in reducing the proportion of cariogenic bacteria, increasing the diversity of plaque microorganisms, and further promoting the microecological balance. 微生物学 2022年11月25日星期五12:26:00 GMT <![Er:YAG欧宝app苹果下载软件激光联合氟化物治疗对多发性龋齿儿童龈上斑块微生物群影响的附加文件1:动态研究 //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_The_impact_of_Er_YAG_laser_combined_with_fluoride_treatment_on_the_supragingival_plaque_microbiome_in_children_with_multiple_caries_a_dynamic_study/21622979//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_The_impact_of_Er_YAG_laser_combined_with_fluoride_treatment_on_the_supragingival_plaque_microbiome_in_children_with_multiple_caries_a_dynamic_study/21622979 欧宝app苹果下载软件附加文件1:表S1。样品的基本信息和序列数据。图S1。每个样品中前10个类群在门水平上的相对丰度。图S2。每个样品中前10个类群在属水平上的相对丰度。图S3。48个样品在门水平上的前16个类群的微生物相对丰度热图。从蓝到红的颜色梯度表示相对丰度由低到高。图S4。 The heat map of microbes relative abundance of the top 100 taxa for 48 samples at the genus level. The color gradient from blue to red indicates the relative abundance from low to high. Figure S5. Expression of bacterial genera with small relative abundance at the genus level. 微生物学 2022年11月25日星期五12:26:00 GMT <![变异亚基和相关因子对全基因组内聚体分布和动力学的贡献 //www.veemusicshop.com/collections/Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/6317661//www.veemusicshop.com/collections/Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/6317661 内聚蛋白复合体组织基因组形成的动态染色质环,影响所有dna介导的过程。脊椎动物体细胞中有两种不同的内聚复合物,分别携带STAG1或STAG2亚基,以及两种版本的调控亚基PDS5, PDS5A和PDS5B。缺乏任何一种变异亚基的小鼠都是胚胎致死的,这表明它们不是功能冗余的。然而,它们在分子水平上的具体行为还没有被完全理解。结果内聚蛋白的全基因组分布提供了重要的功能信息。本研究通过染色质免疫沉淀和深度测序,研究了小鼠胚胎成纤维细胞(mef)内聚蛋白亚基和调控因子的分布,包括野生型和内聚蛋白亚基和调控因子缺失型。除了常见的CTCF内聚位点外,我们还发现了非CTCF内聚结合位点,并表明在这些位点上,cohesive - stag2是首选的变体。此外,根据光漂白后的荧光恢复(FRAP)判断,该配合物与染色质具有更动态的联系,优先与WAPL结合,比内聚- stag1更容易用盐从染色质中提取。我们观察到,PDS5A和PDS5B都专门位于黏着蛋白- ctcf位置,而单个同源同源蛋白的消融对黏着蛋白的分布没有明显的影响,而双敲除的细胞显示所有结合位点的黏着蛋白积累减少。除了我们发现的包括CTCF和WAPL在内的所有调控因子结合的一小部分内聚位置外,NIPBL和PDS5的存在是相互排斥的,这与我们在哺乳动物细胞提取物中的免疫沉淀分析和之前在酵母中的结果一致。 Conclusion Our findings support the idea that non-CTCF cohesin-binding sites represent sites of cohesin loading or pausing and are preferentially occupied by the more dynamic cohesin-STAG2. PDS5 proteins redundantly contribute to arrest cohesin at CTCF sites, possibly by preventing binding of NIPBL, but are not essential for this arrest. These results add important insights towards understanding how cohesin regulates genome folding and the specific contributions of the different variants that coexist in the cell. 遗传学 2022年11月25日星期五12:25:59 GMT <![CDATA[难民住所内/周围难民儿童身体活动的感知环境障碍和促进因素:柏林定性案例研究]> //www.veemusicshop.com/collections/Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/6317666//www.veemusicshop.com/collections/Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/6317666 之前的研究已经确定了建筑环境属性与难民儿童的身体活动(PA)有关;但是,目前还缺乏针对难民儿童在个人层面上对环境的看法的研究。我们研究了难民儿童PA的感知环境障碍和促进因素。方法通过问卷调查和在柏林的一个难民住所举办讲习班,收集难民儿童(n = 15, 6 - 13岁)及其父母(n = 10)对PA环境的感知。此外,对3名儿童进行photovoice,深入了解他们对PA现有环境的体验。研究于2019年6月至7月进行。所有研究材料转录和分析使用专题分析。结果难民儿童及其父母认为微环境是儿童日常PA的中心,他们通常在室内玩耍,但大多数父母认为没有空间。在中观环境中,孩子和父母认为空间不足,担心邻里安全。此外,家长更关心孩子玩耍时的“空间可及性”,而不是“空间质量(如设备)”。 Children also indicated the importance of informal spaces for their PA. Conclusions Refugee children perceive a lack of space and safety when attempting to play in the existing micro and meso environments. Related practitioners should focus on providing more play spaces in micro environments and safe access to existing neighbourhood playfields. These efforts can augment much-needed research on strategies to better integrate refuge facilities to their urban context and essential in minimising current health and spatial inequality issues these vulnerable groups face across Germany and worldwide. 医学、遗传学、生物技术、社会学、科学政策、传染病、植物生物学 2022年11月25日星期五12:25:58 GMT <![CDATA[欧宝app苹果下载软件变异亚基和相关因子对全基因组内聚蛋白分布和动力学的贡献的附加文件5 //www.veemusicshop.com/articles/figure/Additional_file_5_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622974//www.veemusicshop.com/articles/figure/Additional_file_5_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622974 欧宝app苹果下载软件附加文件5:电影S3。RAD21-GFP iFRAP。 遗传学 2022年11月25日星期五12:25:58 GMT <![关于难民儿童欧宝app苹果下载软件在难民营内/周围进行身体活动的环境障碍和促进因素:柏林定性案例研究的附加文件4 //www.veemusicshop.com/articles/journal_contribution/Additional_file_4_of_Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/21622976//www.veemusicshop.com/articles/journal_contribution/Additional_file_4_of_Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/21622976 欧宝app苹果下载软件附加文件4。第二阶段非结构化面试的A1海报示例(过程材料)。 医学、遗传学、生物技术、社会学、科学政策、传染病、植物生物学 2022年11月25日星期五12:25:58 GMT <![难民儿童在难欧宝app苹果下载软件民营内/周围进行身体活动的环境障碍和促进因素:柏林定性案例研究的附加文件3 //www.veemusicshop.com/articles/journal_contribution/Additional_file_3_of_Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/21622973//www.veemusicshop.com/articles/journal_contribution/Additional_file_3_of_Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/21622973 欧宝app苹果下载软件附加文件3。(a)为第一阶段儿童设计的可玩时钟轮;(b) A3纸儿童绘画的环境尺度纸示例。 医学、遗传学、生物技术、社会学、科学政策、传染病、植物生物学 2022年11月25日星期五12:25:57 GMT <![难民儿童在难欧宝app苹果下载软件民营内/周围进行身体活动的环境障碍和促进因素:柏林定性案例研究的附加文件2 //www.veemusicshop.com/articles/journal_contribution/Additional_file_2_of_Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/21622970//www.veemusicshop.com/articles/journal_contribution/Additional_file_2_of_Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/21622970 欧宝app苹果下载软件附加文件2。第一阶段儿童问卷(英文版)。 医学、遗传学、生物技术、社会学、科学政策、传染病、植物生物学 2022年11月25日星期五12:25:56 GMT <![CDATA[欧宝app苹果下载软件变异亚基和相关因素对内聚蛋白全基因组分布和动力学的贡献的附加文件4 //www.veemusicshop.com/articles/figure/Additional_file_4_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622971//www.veemusicshop.com/articles/figure/Additional_file_4_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622971 欧宝app苹果下载软件附加文件4:电影S2。STAG2-GFP iFRAP。 遗传学 2022年11月25日星期五12:25:56 GMT <![CDATA[欧宝app苹果下载软件变异亚基和相关因素对内聚蛋白全基因组分布和动力学的贡献的附加文件3 //www.veemusicshop.com/articles/figure/Additional_file_3_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622965//www.veemusicshop.com/articles/figure/Additional_file_3_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622965 欧宝app苹果下载软件附加文件3:电影S1。STAG1-GFP iFRAP。 遗传学 2022年11月25日星期五12:25:55 GMT <![难民儿童在难欧宝app苹果下载软件民营内/周围进行身体活动的环境障碍和促进因素:柏林定性案例研究的附加文件1 //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/21622967//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Perceived_environmental_barriers_and_facilitators_of_refugee_children_s_physical_activity_in_around_refugee_accommodation_a_qualitative_case_study_in_Berlin/21622967 欧宝app苹果下载软件附加文件1。为家长提供有关子女日常玩耍的问卷(英文版)*。 医学、遗传学、生物技术、社会学、科学政策、传染病、植物生物学 2022年11月25日星期五12:25:55 GMT <![CDATA[来自模式依赖性局灶粘附和细胞骨架的细胞纳米力学,以平衡恶性骨肉瘤的基因转染 //www.veemusicshop.com/collections/Cellular_nanomechanics_derived_from_pattern-dependent_focal_adhesion_and_cytoskeleton_to_balance_gene_transfection_of_malignant_osteosarcoma/6317663//www.veemusicshop.com/collections/Cellular_nanomechanics_derived_from_pattern-dependent_focal_adhesion_and_cytoskeleton_to_balance_gene_transfection_of_malignant_osteosarcoma/6317663 摘要基因转染被认为是最有希望克服绝大多数疾病的技术,在基因治疗的临床应用已得到广泛报道。尽管新的转染材料和方法发展迅速,但恶性骨肉瘤的形态学依赖的纳米力学对基因转染的影响仍不明确。在本研究中,通过制备的微模式调节骨肉瘤细胞的扩散和粘附面积,以调节骨肉瘤细胞的局灶性粘附(FA)形成和细胞骨架组织。微模式依赖性FA和细胞骨架可诱导不同的细胞纳米力学作用影响细胞功能。我们的结果表明,在微模式骨肉瘤中,转染效率随着FA面积的增大和细胞的纳米力学而提高。基因转染在微模式细胞中的差异是由细胞内化能力、Ki67增殖能力和通过调节局部粘附和细胞骨架机制的YAP机械转导有力支持的。本研究旨在揭示细胞纳米力学与基因转染的关系,以实现高效的基因传递,并开发多功能纳米医学生物材料,用于骨肉瘤细胞的精确基因治疗。 生物物理学、细胞生物学、遗传学、分子生物学、发育生物学、癌症、血液学、传染病、植物生物学、空间科学、未分类的环境科学、未分类的生物科学 2022年11月25日星期五12:25:53 GMT <![CDATA[欧宝app苹果下载软件来自模式依赖性局灶粘附和细胞骨架平衡恶性骨肉瘤基因转染的细胞纳米力学的附加文件1]> //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Cellular_nanomechanics_derived_from_pattern-dependent_focal_adhesion_and_cytoskeleton_to_balance_gene_transfection_of_malignant_osteosarcoma/21622961//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Cellular_nanomechanics_derived_from_pattern-dependent_focal_adhesion_and_cytoskeleton_to_balance_gene_transfection_of_malignant_osteosarcoma/21622961 欧宝app苹果下载软件附加文件1:表S1。制备的微图案特征。数据是从3个独立的微模式中计算出来的。表S2。MG63细胞微图案和非图案的直径和扩散面积。数据是从每种类型微模式的五个单元中计算出来的。 生物物理学、细胞生物学、遗传学、分子生物学、发育生物学、癌症、血液学、传染病、植物生物学、空间科学、未分类的环境科学、未分类的生物科学 2022年11月25日星期五12:25:53 GMT <![CDATA[欧宝app苹果下载软件变异亚基和相关因素对内聚蛋白全基因组分布和动力学的贡献的附加文件2 //www.veemusicshop.com/articles/dataset/Additional_file_2_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622962//www.veemusicshop.com/articles/dataset/Additional_file_2_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622962 欧宝app苹果下载软件附加文件2:表S1。基因组数据集。表S2。抗体。表S3。CRISPR的引物。表S4。ChIP-qPCR引物。 遗传学 2022年11月25日星期五12:25:53 GMT <![CDATA[欧宝app苹果下载软件变异亚基和相关因素对内聚蛋白全基因组分布和动力学的贡献的附加文件1 //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622959//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Contribution_of_variant_subunits_and_associated_factors_to_genome-wide_distribution_and_dynamics_of_cohesin/21622959 欧宝app苹果下载软件附加文件1:图。S1条件KO mef的表征。得了。免疫印迹分析用于ChIP分析的WT和Stag2 KO (a), Pds5 DKO (b)和Ctcf KO (c) mef的全细胞提取物。增加WT细胞的数量(以%表示),以量化ko的消耗程度。在b中,相同的膜先与抗pds5b孵育,然后与抗pds5a孵育。星号表示来自PDS5B的前一个信号。在c中,还包括了用于静态mef中CTCF损耗的实验装置方案。数字S2基因组内聚亚基和调控因子的分布。 Snapshots of the UCSC genome browser at several loci that contain neighboring CTCF and non-CTCF cohesin sites. Examples of non-CTCF cohesin positions that are bound by RNA polymerase II or not are shown in top and bottom rows, respectively. A track showing SMC1 in Stag2 KO cells is also included (in red). Figure. S3 Transcription factor motifs at non-CTCF cohesin sites. STREME analysis showing the most statistically significant motifs enriched in non-CTCF cohesin positions in different cell lines. Percentages next to p-values represent the fraction of positions containing each motif. Logos on the right correspond to transcription factor binding sites statistically associated with those motifs that are shared among different cell lines. Figure. S4 GFP-tagged cohesin subunits form complexes and bind to chromatin. a. Polyclonal populations of iMEFs expressing GFP-tagged versions of RAD21, STAG1 or STAG2 were pre-extracted before fixation and stained with SMC1 (red) and DAPI (blue). Cells showing the corresponding GFP-tagged protein bound to chromatin are encircled. These cells were used in iFRAP analyses shown in Fig. 3c. b. Immunoblot analyses of whole cell extracts of these iMEFs. c. Chromatin fractionation analyses confirm that the tagged proteins are bound to chromatin. d. Immunoprecipitation reactions with SMC1 antibodies (or IgG as negative control) show the incorporation of GFP-tagged proteins in to cohesin complexes. For RAD21-GFP iMEFs, see Morales et al. [5]. Figure. S5 PDS5 proteins and cohesin distribution. a. Matrix showing the correlation between the genome-wide distributions of the indicated proteins (called peaks). b. Heatmaps showing the distribution of SMC1 in MEFs lacking PDS5A or PDS5B. c. Snapshots of the genome browser showing ChIP-seq data for SMC1 in WT and Pds5 DKO MEFs in regions that were validated by ChIP-qPCR. Graphs represent fold enrichment of the ChIP signal in each region (r1 to r14) over a neighbor negative region (neg). Figure. S6 Distribution of cohesin subunits in non-CTCF and CTCF positions after depletion of regulators. Read density plots for the heatmaps shown in Fig. 5, separating the four clusters defined in Fig. 4. Cluster 1, non-CTCF cohesin positions; cluster 2, CTCF cohesin sites with high NIPBL and low PDS5; cluster 3, CTCF cohesin sites with high NIPBL, PDS5 and CTCF; cluster 4, CTCF cohesin with low NIPBL 遗传学 2022年11月25日星期五12:25:52 GMT <![安全分娩的人权:来自193个国家的数据显示,性别平等确实影响孕产妇死亡率]> //www.veemusicshop.com/collections/The_human_right_to_safely_give_birth_data_from_193_countries_show_that_gender_equality_does_affect_maternal_mortality/6317660//www.veemusicshop.com/collections/The_human_right_to_safely_give_birth_data_from_193_countries_show_that_gender_equality_does_affect_maternal_mortality/6317660 尽管全球孕产妇死亡率(MMR)的下降速度有所放缓,但需要更新的战略来实现持续和可持续的降低MMR。以前的研究调查了与卫生系统相关的因素,如财富不平等、卫生保健的获得和使用与孕产妇死亡率之间的关系。然而,排除与卫生系统有关的因素,尚未研究以妇女权利为基础的方法来解决MMR问题。本研究旨在分析全球性别平等与MMR之间的关系。方法采用结构方程模型(SEM),对来自联合国和其他193个国家的国际机构的二级和开放获取数据进行分析。选择了代表研究的理论和概念框架的性别敏感变量。潜在变量性别平等和结果MMR之间的关系在扫描电镜中进行了检查。第二个SEM模型(n = 158)的设计包括与基于性别的暴力相关的两个变量。潜在变量性别平等与产妇死亡率呈负相关(模型1中,p < 0·001,Z = -6·96,95% CI:−6508.98 ~−3141.89,模型2中,p < 0·001,Z = -7·23,95% CI:−6045.356 ~−3467.515)。投资于妇女的高等教育、改善她们的有偿就业机会、增加她们参与领导角色和政治、减少亲密伴侣暴力和结束童婚都可以显著降低孕产妇死亡率。 医学、生物技术、社会学、科学政策、其他未分类的生物科学 2022年11月25日星期五12:25:51格林尼治标准时间 <![安全分娩的人欧宝app苹果下载软件权:来自193个国家的数据显示,性别平等确实影响孕产妇死亡率 //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_The_human_right_to_safely_give_birth_data_from_193_countries_show_that_gender_equality_does_affect_maternal_mortality/21622958//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_The_human_right_to_safely_give_birth_data_from_193_countries_show_that_gender_equality_does_affect_maternal_mortality/21622958 欧宝app苹果下载软件附加文件1。 医学、生物技术、社会学、科学政策、其他未分类的生物科学 周五,2022年11月25日12:25:50 GMT <![洋蓟水提取物可改善大鼠高脂饮食诱导的非酒精性脂肪肝疾病 //www.veemusicshop.com/collections/Water_extract_from_artichoke_ameliorates_high-fat_diet-induced_non-alcoholic_fatty_liver_disease_in_rats/6317657//www.veemusicshop.com/collections/Water_extract_from_artichoke_ameliorates_high-fat_diet-induced_non-alcoholic_fatty_liver_disease_in_rats/6317657 “多重打击”假说是目前公认的非酒精性脂肪性肝病(NAFLD)发病机制理论。本研究旨在探讨洋蓟水提物(WEA)对NAFLD的影响及其潜在机制。方法大鼠先喂高脂饲料(HFD)诱导NAFLD 8周,然后分别给予WEA 0.4、0.8、1.6 g/kg体重(BW) 3个剂量8周。干预结束时测定血清生化指标、肝脏抗氧化能力、肝脏促炎细胞因子水平、肝脏组织病理学、肝脏炎症基因和脂质代谢基因表达、Akt和p-Akt (S473)蛋白水平。结果与HFD组相比,wea组(0.8和1.6 g/kg BW)大鼠体重、肝脏重量、肝甘油三酯(TG)及血清TG、总胆固醇、低密度脂蛋白胆固醇、谷丙转氨酶、天冬氨酸转氨酶、葡萄糖、胰岛素水平均显著降低(P < 0.01)。与HFD组相比,wea处理组(0.8和1.6 g/kg BW)肝脏丙二醛(P < 0.01)和谷胱甘肽(P < 0.01)含量显著降低,肝脏超氧化物歧化酶活性显著升高(P < 0.01)。此外,与HFD组相比,wea治疗组肝脏促炎细胞因子(TNF-α、IL-1β和IL-6)水平明显降低(P < 0.01)。与这些发现一致的是,WEA(0.8和1.6 g/kg BW)治疗的大鼠肝脏组织病理学显示脂肪变性、膨胀和小叶炎症有所减少。从机制上看,肝脏TG含量的降低可能与脂肪生成基因(SREBP1c、FASN、SCD1)的下调和脂聚基因(PPARα)的上调有关,胰岛素信号的改善可能与wea治疗组抗氧化活性的提高和炎症的减轻有关。结论WEA对NAFLD的肝保护作用可能与其抗脂肪、抗氧化、抗炎、抗胰岛素抵抗等作用有关。 生物化学、医学、遗传学、分子生物学、生理学、药理学、免疫学、其他未分类的化学科学 2022年11月25日星期五12:25:49 GMT <!洋蓟水提取物改欧宝app苹果下载软件善高脂饮食诱导的大鼠非酒精性脂肪肝疾病的附加文件1 //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Water_extract_from_artichoke_ameliorates_high-fat_diet-induced_non-alcoholic_fatty_liver_disease_in_rats/21622955//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Water_extract_from_artichoke_ameliorates_high-fat_diet-induced_non-alcoholic_fatty_liver_disease_in_rats/21622955 欧宝app苹果下载软件附加文件1。 生物化学、医学、遗传学、分子生物学、生理学、药理学、免疫学、其他未分类的化学科学 2022年11月25日星期五12:25:48 GMT <![败血症中低镁血症与凝血功能障碍的相关性:一项回顾性观察性研究 //www.veemusicshop.com/collections/Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/6317654//www.veemusicshop.com/collections/Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/6317654 据报道,低镁血症与脓毒症患者的死亡率增加和脓毒症休克等不良临床结果显著相关。尽管这些结果背后的机制尚不清楚,但一些实验数据表明,镁缺乏可能增强脓毒症中的凝血激活。然而,在败血症中,血清镁水平与凝血病变(包括弥漫性血管内凝血(DIC))之间的关系尚不清楚。因此,我们旨在研究脓毒症患者血清镁水平与凝血状态之间的关系以及低镁血症与DIC之间的关系。方法回顾性观察研究于2011年6月至2017年12月在某大学医院重症监护室(ICU)进行。19岁以上符合脓毒症-3定义的患者纳入研究。我们根据血清镁水平将患者分为三组:低镁血症(< 1.6 mg/dL)、正常血清镁水平(1.6 - 2.4 mg/dL)和高镁血症(> 2.4 mg/dL)。我们根据国际血栓与止血学会的标准调查ICU入院时血清镁水平与明显DIC之间的关系。结果753例患者中,DIC 181例,低镁血症105例,血清镁水平正常552例,高镁血症96例。与正常血清镁水平和高镁血症患者相比,低镁血症患者的凝血状态更为活跃,表现为血小板计数较低,纤维蛋白原水平较低,凝血酶原时间-国际归一化比较高,凝血酶-抗凝血酶复合体较高,DIC发生率较高(DIC: 41.9% vs. 20.6% vs. 24.0%, P < 0.001)。 The coagulation status in patients with hypomagnesemia was more augmented toward suppressed fibrinolysis than that in patients with normal serum magnesium levels and hypermagnesemia. Multivariate logistic regression revealed that hypomagnesemia was independently associated with DIC (odds ratio, 1.69; 95% confidence interval, 1.00–2.84; P = 0.048) after adjusting for several confounding variables. Conclusions Patients with hypomagnesemia had a significantly activated coagulation status and suppressed fibrinolysis. Hypomagnesemia was independently associated with DIC in patients with sepsis. Therefore, the treatment of hypomagnesemia may be a potential therapeutic strategy for the treatment of coagulopathy in sepsis. 生物化学、医学、细胞生物学、分子生物学、免疫学、科学政策、血液学、其他未分类的数学科学 周五,2022年11月25日12:25:47 GMT <![一种新的诺姆图,在检查人口统计学、饮食习惯、治疗干预和心理健康状况后,对脊柱转移性晚期癌症患者的生活质量进行分层 //www.veemusicshop.com/collections/A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/6317655//www.veemusicshop.com/collections/A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/6317655 背景如果在特定人群中发现影响生活质量的危险因素,将非常有助于对患者进行分层和指导患者选择。尽管如此,预测脊髓转移患者与健康相关的生活质量仍然具有挑战性。本研究的目的是通过开发和验证诺姆图来预测脊柱转移的晚期癌症患者的生活质量,对患者群体进行分层,以鼓励对其生活质量进行评估。方法前瞻性分析208例晚期肿瘤脊柱转移患者的一般特征、食物偏好、成瘾、共病、治疗策略及心理健康状况。采用癌症治疗总量表(FACT-G)和医院焦虑抑郁量表(HADS)分别评估生活质量和心理健康。完整的患者队列被随机分为两组:训练集和验证集。来自训练集的患者进行训练和开发诺图,而在验证集的患者进行内部验证诺图。诺图包含了使用最小绝对收缩和选择算子(LASSO)方法结合10倍交叉验证发现的显著变量。利用鉴别、校准和临床有用性评估nomogram预测能力。内部验证也在应用500次迭代过程后使用bootstrap方法完成。 A web calculator was also developed to promote clinical practice. Results Advance cancer patients with spinal metastases had an extremely low quality of life, as indicated by the average FACT-G score of just 60.32 ± 20.41. According to the LASSO and 10-fold cross-validation, Eastern Cooperative Oncology Group (ECOG) score, having an uncompleted life goal, preference for eating vegetables, chemotherapy, anxiety status, and depression status were selected as nomogram predictors. In the training set, the area under the receiver operating characteristic curve (AUROC) was 0.90 (95% CI: 0.84–0.96), while in the validation set, it was 0.85 (95% CI: 0.78–0.93). They were 0.50 (95% CI: 0.41–0.58) and 0.44 (95% CI: 0.33–0.56), respectively, for the discrimination slopes. The nomogram had favorable capacity to calibrate and was clinically useful, according to the calibration curve and decision curve analysis. When compared to patients in the low-risk group, patients in the high-risk group were above four times more likely to experience a poor quality of life (82.18% vs. 21.50%, P < 0.001). In comparison to patients in the low-risk group, patients in the high-risk group also exhibited significant higher levels of anxiety and depression. The webpage for the web calculator was https://starshiny.shinyapps.io/DynNomapp-lys/ . Conclusions This study suggests a nomogram that can be applied as a practical clinical tool to forecast and categorize the quality of life among patients with spine metastases. Additionally, patients with poor quality of life experience more severe anxiety and depression. Effective interventions should be carried out as soon as possible, especially for patients in the high-risk group, to improve their quality of life and mental health condition. 医学、生物技术、发育生物学、科学政策、血液学、其他未分类的生物科学 2022年11月25日星期五12:25:46格林尼治标准时间 <![CDATA[欧宝app苹果下载软件败血症中低镁血症和凝血功能障碍之间的关系:一项回顾性观察性研究的附加文件9 //www.veemusicshop.com/articles/journal_contribution/Additional_file_9_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622952//www.veemusicshop.com/articles/journal_contribution/Additional_file_9_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622952 欧宝app苹果下载软件附加文件9:腹部败血症患者弥散性血管内凝血的Logistic回归分析。 生物化学、医学、细胞生物学、分子生物学、免疫学、科学政策、血液学、其他未分类的数学科学 2022年11月25日星期五12:25:45 GMT <![CDATA[欧宝app苹果下载软件败血症中低镁血症与凝血功能障碍之间的关系:一项回顾性观察性研究的附加文件8 //www.veemusicshop.com/articles/journal_contribution/Additional_file_8_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622949//www.veemusicshop.com/articles/journal_contribution/Additional_file_8_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622949 欧宝app苹果下载软件附加文件8:DIC患者血清镁浓度的受试者工作特征曲线。 生物化学、医学、细胞生物学、分子生物学、免疫学、科学政策、血液学、其他未分类的数学科学 2022年11月25日星期五12:25:44 GMT <![CDATA[欧宝app苹果下载软件一种新型诺姆图在检查人口统计学、饮食习惯、治疗干预和心理健康状态后对脊柱转移性晚期癌症患者的生活质量进行分层的附加文件9 //www.veemusicshop.com/articles/journal_contribution/Additional_file_9_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622950//www.veemusicshop.com/articles/journal_contribution/Additional_file_9_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622950 欧宝app苹果下载软件附加文件9。 医学、生物技术、发育生物学、科学政策、血液学、其他未分类的生物科学 2022年11月25日星期五12:25:44 GMT <![CDATA[欧宝app苹果下载软件败血症中低镁血症和凝血功能障碍之间的关系:一项回顾性观察性研究的附加文件7 //www.veemusicshop.com/articles/journal_contribution/Additional_file_7_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622946//www.veemusicshop.com/articles/journal_contribution/Additional_file_7_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622946 欧宝app苹果下载软件附加文件7:第3天重度低镁血症和非低镁血症患者凝血参数的时间变化。 生物化学、医学、细胞生物学、分子生物学、免疫学、科学政策、血液学、其他未分类的数学科学 2022年11月25日星期五12:25:43格林尼治标准时间 <![CDATA[欧宝app苹果下载软件一种新型诺姆图在检查人口统计学、饮食习惯、治疗干预和心理健康状况后对脊柱转移性晚期癌症患者的生活质量进行分层的附加文件8 //www.veemusicshop.com/articles/journal_contribution/Additional_file_8_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622947//www.veemusicshop.com/articles/journal_contribution/Additional_file_8_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622947 欧宝app苹果下载软件附加文件8。 医学、生物技术、发育生物学、科学政策、血液学、其他未分类的生物科学 2022年11月25日星期五12:25:43格林尼治标准时间 <![CDATA[欧宝app苹果下载软件败血症中低镁血症与凝血功能障碍之间的关系:一项回顾性观察性研究的附加文件6 //www.veemusicshop.com/articles/journal_contribution/Additional_file_6_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622943//www.veemusicshop.com/articles/journal_contribution/Additional_file_6_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622943 欧宝app苹果下载软件附加文件6:第3天持续性低镁血症和解决性低镁血症患者凝血参数的时间变化。 生物化学、医学、细胞生物学、分子生物学、免疫学、科学政策、血液学、其他未分类的数学科学 2022年11月25日星期五12:25:42 GMT <![CDATA[欧宝app苹果下载软件一种新型诺姆图在检查人口统计学、饮食习惯、治疗干预和心理健康状况后对脊柱转移性晚期癌症患者的生活质量进行分层的附加文件7 //www.veemusicshop.com/articles/journal_contribution/Additional_file_7_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622944//www.veemusicshop.com/articles/journal_contribution/Additional_file_7_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622944 欧宝app苹果下载软件附加文件7。 医学、生物技术、发育生物学、科学政策、血液学、其他未分类的生物科学 2022年11月25日星期五12:25:42 GMT <![CDATA[欧宝app苹果下载软件一种新型诺姆图在检查人口统计学、饮食习惯、治疗干预和心理健康状态后对脊柱转移性晚期癌症患者的生活质量进行分层的附加文件6 //www.veemusicshop.com/articles/journal_contribution/Additional_file_6_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622941//www.veemusicshop.com/articles/journal_contribution/Additional_file_6_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622941 欧宝app苹果下载软件附加文件6。 医学、生物技术、发育生物学、科学政策、血液学、其他未分类的生物科学 2022年11月25日星期五12:25:41 GMT <![CDATA[欧宝app苹果下载软件一种新型诺姆图在检查人口统计学、饮食习惯、治疗干预和心理健康状况后对脊柱转移性晚期癌症患者的生活质量进行分层的附加文件5 //www.veemusicshop.com/articles/journal_contribution/Additional_file_5_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622938//www.veemusicshop.com/articles/journal_contribution/Additional_file_5_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622938 欧宝app苹果下载软件附加文件5。 医学、生物技术、发育生物学、科学政策、血液学、其他未分类的生物科学 2022年11月25日星期五12:25:40 GMT <![CDATA[欧宝app苹果下载软件败血症中低镁血症与凝血功能障碍之间的关系:一项回顾性观察性研究的附加文件5 //www.veemusicshop.com/articles/journal_contribution/Additional_file_5_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622940//www.veemusicshop.com/articles/journal_contribution/Additional_file_5_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622940 欧宝app苹果下载软件附加文件5:脓毒症患者第5天不同血清镁水平(低镁、正常镁和高镁)之间的凝血参数。 生物化学、医学、细胞生物学、分子生物学、免疫学、科学政策、血液学、其他未分类的数学科学 2022年11月25日星期五12:25:40 GMT <![CDATA[欧宝app苹果下载软件一种新型诺姆图在检查人口统计学、饮食习惯、治疗干预和心理健康状态后对晚期脊柱转移性癌症患者的生活质量进行分层的附加文件4 //www.veemusicshop.com/articles/journal_contribution/Additional_file_4_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622935//www.veemusicshop.com/articles/journal_contribution/Additional_file_4_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622935 欧宝app苹果下载软件附加文件4。 医学、生物技术、发育生物学、科学政策、血液学、其他未分类的生物科学 2022年11月25日星期五12:25:39 GMT <![CDATA[欧宝app苹果下载软件败血症中低镁血症与凝血功能障碍之间的关系:一项回顾性观察性研究的附加文件4 //www.veemusicshop.com/articles/journal_contribution/Additional_file_4_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622937//www.veemusicshop.com/articles/journal_contribution/Additional_file_4_of_Association_between_hypomagnesemia_and_coagulopathy_in_sepsis_a_retrospective_observational_study/21622937 欧宝app苹果下载软件附加文件4:脓毒症患者第3天不同血清镁水平(低镁、正常镁和高镁)之间的凝血参数。 生物化学、医学、细胞生物学、分子生物学、免疫学、科学政策、血液学、其他未分类的数学科学 2022年11月25日星期五12:25:39 GMT <![CDATA[欧宝app苹果下载软件一种新的诺姆图,在检查人口统计学、饮食习惯、治疗干预和心理健康状态后,对脊柱转移性晚期癌症患者的生活质量进行分层的附加文件3 //www.veemusicshop.com/articles/journal_contribution/Additional_file_3_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622932//www.veemusicshop.com/articles/journal_contribution/Additional_file_3_of_A_novel_nomogram_to_stratify_quality_of_life_among_advanced_cancer_patients_with_spinal_metastatic_disease_after_examining_demographics_dietary_habits_therapeutic_interventions_and_mental_health_status/21622932 欧宝app苹果下载软件附加文件3。 医学、生物技术、发育生物学、科学政策、血液学、其他未分类的生物科学 2022年11月25日星期五12:25:38 GMT
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