//www.veemusicshop.com/ RSS提要Figshare机构Springer自然欧宝娱乐尤文图斯官方合作伙伴 eyJhbGciOiJIUzUxMiJ9.eyJ2YWx1ZXMiOlsxNjg1ODQ4MzcxMDAwLDY2Nzk4MTJdfQ.S3bOOmt_gYWmJlHpLx1vqxnzz4G8KyKcLQY9EMXqMVqy-7bkSe9dbt6_b7_1CcAw8qob6rJcI6uBT8pe99aOQw //www.veemusicshop.com/collections/Surface_Electromyogram_Kinematic_and_Kinetic_Dataset_of_Lower_Limb_Walking_for_Movement_Intent_Recognition/6271164//www.veemusicshop.com/collections/Surface_Electromyogram_Kinematic_and_Kinetic_Dataset_of_Lower_Limb_Walking_for_Movement_Intent_Recognition/6271164 本研究提出了一种新颖的下肢运动数据集(SIAT-LLMD),包括摘要、运动学和动力学数据与相应的标签从40获得健康的人类在16肢体动作。 分析生物化学 妈,05年6月2023 11:34:00 GMT //www.veemusicshop.com/articles/dataset/Shenzhen_Institute_of_Advanced_Technology_Lower_Limb_Motion_Dataset_SIAT-LLMD_/22776389//www.veemusicshop.com/articles/dataset/Shenzhen_Institute_of_Advanced_Technology_Lower_Limb_Motion_Dataset_SIAT-LLMD_/22776389 本研究提出了一种新颖的下肢运动数据集(SIAT-LLMD),包括摘要、运动学和动力学数据与相应的标签从40获得健康的人类在16肢体动作。 分析生物化学 妈,05年6月2023 11:33:59 GMT //www.veemusicshop.com/collections/Spatiotemporal_parameters_for_energy_efficient_kilohertz-frequency_nerve_block_with_low_onset_response/6680284//www.veemusicshop.com/collections/Spatiotemporal_parameters_for_energy_efficient_kilohertz-frequency_nerve_block_with_low_onset_response/6680284 抽象背景电神经传导阻滞为疾病治疗有很大潜力通过可逆的和当地的失活体细胞和自主神经。然而,相对较高的能源需求和无用的存在激发kilohertz-frequency爆发(KHF)信号用于块构成障碍有效的翻译。频率、电极几何形状和波形形状已知影响块阈值和发生反应,但现有的数据提供一个有限的理解如何选择这些参数来优化神经阻滞。方法评估KHF神经阻滞在大鼠胫骨神经在频率(5-60千赫),电极几何形状(单极、双极和三极的),和波形的形状。我们提出一个新的Fourier-based方法构建复合信号,系统的样本KHF波形设计空间。结果最低频率能够阻止(5-16千赫)不是最节能的测试频率。此外,双相袖口要求最大的电流和功率,单极袖口要求最低电流、三极的和单极袖口要求最低的权力。三极的袖口产生最小的发作频率响应。复合信号组成的第一次谐波正弦信号基频(f0)在二次谐波正弦信号叠加在发病2 f0可以阻止低阈值和较低的反应相比,成分血窦。这种影响是强烈依赖阶段的二次谐波和相对的第一和第二次谐波振幅。 This effect was also dependent on electrode geometry: monopolar and tripolar cuffs showed clear composite signal effects in most experiments; bipolar cuffs showed no clear effects in most experiments. Conclusions Our data provide novel information about block threshold and onset response at the boundary of frequencies that can block. Our results also show an interaction between spatial (cuff geometry) and temporal (frequency and waveform shape) parameters. Finally, while previous studies suggested that temporal parameters could reduce onset response only in exchange for increased block threshold (or vice versa), our results show that waveform shape influences KHF response in ways that can be exploited to reduce both energy and onset responses. 生物物理学、神经科学、生理学、药理学、生物技术、免疫学、科学政策、植物生物学,生物科学不是其他地方分类 妈,05年6月2023 03:08:25 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Spatiotemporal_parameters_for_energy_efficient_kilohertz-frequency_nerve_block_with_low_onset_response/23293339//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Spatiotemporal_parameters_for_energy_efficient_kilohertz-frequency_nerve_block_with_low_onset_response/23293339 欧宝app苹果下载软件额外的文件1。额外的表和数据。 生物物理学、神经科学、生理学、药理学、生物技术、免疫学、科学政策、植物生物学,生物科学不是其他地方分类 妈,05年6月2023 03:08:24 GMT //www.veemusicshop.com/collections/Application_of_the_Khorana_score_for_cancer-associated_thrombosis_prediction_in_patients_of_East_Asian_ethnicity_undergoing_ambulatory_chemotherapy/6680283//www.veemusicshop.com/collections/Application_of_the_Khorana_score_for_cancer-associated_thrombosis_prediction_in_patients_of_East_Asian_ethnicity_undergoing_ambulatory_chemotherapy/6680283 抽象背景Khorana分数(KS)并没有被很好的研究东亚癌症患者,他们有不同的遗传背景对遗传性血栓形成倾向,身体新陈代谢,和癌症流行病学。方法通过使用公共数据模型,我们回顾性收集鉴定数据连续从11714年新诊断癌症病人一线化疗一个单独的机构从2015年12月到2021年12月在韩国,我们应用了KS癌症相关的血栓形成(CAT)预测。诊断年龄、性别、和使用高度形成血栓的化疗是另外调查作为一个潜在的危险因素在猫的发展。结果化疗开始后6个月,207例患者(1.77%)有经验的猫。只有0.4%的人有一个身体质量指数(BMI)≥35 kg / m2和改变截止到25 kg / m2改善猫的预测。年龄≥65岁,使用高度形成血栓的化疗是独立与猫有关的发展。KS的值1 ~ 2和≥3占所有患者的52.3%和7.6%,分别和猫在这些组的发生率为2.16%和4.16%,分别显示较低的发病率比西方人研究人群的猫。KS组件有关癌症的网站显示一个好的协会与猫发展但需要一些改进。结论KS部分验证预测韩国接受现代化疗的癌症患者的猫。修改BMI截止,添加其他风险变量,猫和精炼癌症部位的使用数据风险预测可以提高性能的KS猫预测在东亚的病人。 医学、遗传学、生物技术、发育生物学、癌症、血液学、数学科学不是其他分类,化学科学不是其他国家机密 妈,05年6月2023 03:08:23 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Application_of_the_Khorana_score_for_cancer-associated_thrombosis_prediction_in_patients_of_East_Asian_ethnicity_undergoing_ambulatory_chemotherapy/23293338//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Application_of_the_Khorana_score_for_cancer-associated_thrombosis_prediction_in_patients_of_East_Asian_ethnicity_undergoing_ambulatory_chemotherapy/23293338 补充材料1 医学、遗传学、生物技术、发育生物学、癌症、血液学、数学科学不是其他分类,化学科学不是其他国家机密 妈,05年6月2023 03:08:23 GMT //www.veemusicshop.com/collections/Home_confinement_s_impact_on_myopia_control_by_using_orthokeratology_in_school-aged_children/6680272//www.veemusicshop.com/collections/Home_confinement_s_impact_on_myopia_control_by_using_orthokeratology_in_school-aged_children/6680272 抽象背景家庭监禁期间流行的对学龄儿童的生活方式和行为产生重大影响,他们表现出增加患病率和近视的发展。我们的研究将着眼于家庭监禁是否会影响学龄儿童近视控制角膜矫正术。方法的轴向长度数据搜集自学龄儿童接受好的眼镜治疗。整个数据分为子组是基于性别,年龄,和最初的折射,每个时期的AL变化计算使用公式定义在我们的研究中。最后,使用各种统计方法获得的数据将被检查,和缓慢的想法,温和,和快速近视进展将被应用到我们的学习。结果共有258名研究对象符合要求被包括在这项研究。我们发现近视的比例快速增长期间增加流行病。此外,艾尔改变之前和期间流行于171年发现统计上显著的学科在整个数据。在高年龄组(P = 0.041),阿尔更改之前和期间流行,流行之前和之后(P = 0.033) (P = 0.023)被发现具有统计学意义。艾尔更改之前和期间流行(P = 0.035)被证明是统计上显著中度近视组。 Finally, we did not find statistically significant results for other groups. Conclusion We cannot conclude that home confinement did have a negative impact on myopia control with orthokeratology in school-aged children. But we found there was an increase in the percentage of patients with OK treatment that had fast myopia progression during the confinement. We also observed that older children with higher initial refraction were more likely to be affected by home confinement. Medicine, Biotechnology, Infectious Diseases, Computational Biology, Space Science 妈,05年6月2023 03:08:22 GMT //www.veemusicshop.com/collections/Aspartoacylase_suppresses_prostate_cancer_progression_by_blocking_LYN_activation/6680280//www.veemusicshop.com/collections/Aspartoacylase_suppresses_prostate_cancer_progression_by_blocking_LYN_activation/6680280 全球抽象背景,尽管前列腺癌(PCa)代表男,第二最常见恶性肿瘤的精确分子机制参与其发病机制仍不清楚。因此,阐明控制疾病进展的关键分子监管者可以大大有助于建立新的治疗策略,最终推进PCa的管理。总共49 PCa方法组织和43个相邻正常组织收集从2017年1月至2021年12月在武汉大学中南医院。先进的转录组的方法被用来确认差异表达mrna在PCa。的表达aspartoacylase (ASPA)在PCa彻底评估使用定量实时聚合酶链反应和免疫印迹技术。阐明在PCa ASPA细胞增殖的抑制作用和转移,一组全面的体外和体内进行了化验,包括原位和肿瘤小鼠模型组(n = 8)。相结合的实验方法,如免疫印迹、荧光素酶检测,免疫沉淀反应分析,质谱,谷胱甘肽S-transferase拉实验,和救援的研究中,被调查的潜在分子机制在PCa ASPA的行动。学生的学习任务是用来评估两个截然不同的群体之间的统计学意义,而单向方差分析涉及多用于比较两组。一个双边P值小于0.05被认为是显示统计学意义。结果ASPA被确认为一种新型抑制剂的PCa进展。 The expression of ASPA was found to be significantly down-regulated in PCa tissue samples, and its decreased expression was independently associated with patients’ prognosis (HR = 0.60, 95% CI 0.40–0.92, P = 0.018). Our experiments demonstrated that modulation of ASPA activity, either through gain- or loss-of-function, led to the suppression or enhancement of PCa cell proliferation, migration, and invasion, respectively. The inhibitory role of ASPA in PCa was further confirmed using orthotopic and tumor-bearing mouse models. Mechanistically, ASPA was shown to directly interact with the LYN and inhibit the phosphorylation of LYN as well as its downstream targets, JNK1/2 and C-Jun, in both PCa cells and mouse models, in an enzyme-independent manner. Importantly, the inhibition of LYN activation by bafetinib abrogated the promoting effect of ASPA knockdown on PCa progression in both in vitro and in vivo models. Moreover, we observed an inverse relationship between ASPA expression and LYN activity in clinical PCa samples, suggesting a potential regulatory role of ASPA in modulating LYN signaling. Conclusion Our findings provide novel insights into the tumor-suppressive function of ASPA in PCa and highlight its potential as a prognostic biomarker and therapeutic target for the management of this malignancy. 生物化学、遗传学、癌症、生物科学不是其他国家机密 妈,05年6月2023 03:08:21 GMT //www.veemusicshop.com/articles/dataset/Additional_file_3_of_Home_confinement_s_impact_on_myopia_control_by_using_orthokeratology_in_school-aged_children/23293333//www.veemusicshop.com/articles/dataset/Additional_file_3_of_Home_confinement_s_impact_on_myopia_control_by_using_orthokeratology_in_school-aged_children/23293333 欧宝app苹果下载软件额外的文件3。 Medicine, Biotechnology, Infectious Diseases, Computational Biology, Space Science 妈,05年6月2023 03:08:20 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Aspartoacylase_suppresses_prostate_cancer_progression_by_blocking_LYN_activation/23293335//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Aspartoacylase_suppresses_prostate_cancer_progression_by_blocking_LYN_activation/23293335 欧宝app苹果下载软件额外的文件1:表S1。病人的特点为RNA-Seq提供样品。表S2。病人的特点为西方墨点法提供样品。表S3。病人的特点为包含IHC提供样品。表S4。病人的特点为RT-qPCR提供样品。图S1。ASPA是抑制在PCa的病人。 Fig. S2. ASPA overexpression inhibits DU145 cell proliferation and migration in vitro. Fig. S3. ASPA knockdown promotes DU145 cell proliferation and migration in vitro. Fig. S4. ASPA negatively regulates JNK1/2-C-Jun activity in PC-3 cells. Fig. S5. LYN mediates the function of ASPA in PC-3 cells. 生物化学、遗传学、癌症、生物科学不是其他国家机密 妈,05年6月2023 03:08:20 GMT //www.veemusicshop.com/articles/dataset/Additional_file_2_of_Home_confinement_s_impact_on_myopia_control_by_using_orthokeratology_in_school-aged_children/23293330//www.veemusicshop.com/articles/dataset/Additional_file_2_of_Home_confinement_s_impact_on_myopia_control_by_using_orthokeratology_in_school-aged_children/23293330 欧宝app苹果下载软件额外的文件2。 Medicine, Biotechnology, Infectious Diseases, Computational Biology, Space Science 妈,05年6月2023 03:08:19 GMT //www.veemusicshop.com/collections/Budget_impact_analysis_of_a_digital_monitoring_platform_for_COPD/6680274//www.veemusicshop.com/collections/Budget_impact_analysis_of_a_digital_monitoring_platform_for_COPD/6680274 抽象背景慢性阻塞性肺疾病(COPD)是一个逐步衰弱状态频繁发作,病人和社会的高负担。数字工具可能有助于减少病人的经济负担和纳税人通过改善结果。螺旋桨平台是一个数字自我管理工具,促进药物吸入器利用被动监控,可能协助医疗小组在COPD恶化的风险识别病人可能需要进一步干预。这项研究估计的预算影响螺旋桨从商业支付和医疗保险费用支付的观点。方法一个excel模型被用来估计螺旋桨的预算影响慢性阻塞性肺病患者在商业和医疗保险人口大小的500万个成员。流行的数据,基本医疗资源利用率(HCRU)和基线使用救援和控制器吸入药物与单位成本(调整到2020美元)来自同行评议的文献。减少数据在HCRU螺旋桨的使用是基于直接证据。远程监控的成本估计是来自公开信息。所有患者都认为保险索赔有关正在进行的远程监控。结果年度符合条件的慢性阻塞性肺病患者的估计数字为商业和医疗保险是212200年和606600年,分别。 Propeller decreased costs by an estimated $2,475 (commercial) and $915 (Medicare) per enrolled patient. The greatest increase in expenditure was for remote monitoring related expenses. After accounting for estimated reductions in hospitalizations, emergency department visits and short-acting beta-agonist use, total net savings were approximately $1.60 and $1.70 per-member per-month for commercial and Medicare payers, respectively. Conclusion Propeller is projected to be cost saving from both the commercial and Medicare payer perspectives. 医学、生物技术、生物科学社会学、科学政策,不是其他国家机密 妈,05年6月2023 03:08:17 GMT //www.veemusicshop.com/articles/dataset/Additional_file_1_of_Home_confinement_s_impact_on_myopia_control_by_using_orthokeratology_in_school-aged_children/23293327//www.veemusicshop.com/articles/dataset/Additional_file_1_of_Home_confinement_s_impact_on_myopia_control_by_using_orthokeratology_in_school-aged_children/23293327 欧宝app苹果下载软件额外的文件1。 Medicine, Biotechnology, Infectious Diseases, Computational Biology, Space Science 妈,05年6月2023 03:08:17 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Budget_impact_analysis_of_a_digital_monitoring_platform_for_COPD/23293329//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Budget_impact_analysis_of_a_digital_monitoring_platform_for_COPD/23293329 欧宝app苹果下载软件额外的文件1。补充方法:1.1节医疗医疗资源使用的输入;1.2节吸入药物的使用和相关单位成本投入;1.3节的影响医疗HCRU螺旋桨;表S1。年度平均招生状况和严重程度估计成本的商业纳税人;表S2。年度平均招生状况和严重程度估计成本的医疗保险。 医学、生物技术、生物科学社会学、科学政策,不是其他国家机密 妈,05年6月2023 03:08:17 GMT //www.veemusicshop.com/collections/Incidence_survival_and_associated_factors_estimation_in_osteosarcoma_patients_with_lung_metastasis_a_single-center_experience_of_11_years_in_Tianjin_China/6680259//www.veemusicshop.com/collections/Incidence_survival_and_associated_factors_estimation_in_osteosarcoma_patients_with_lung_metastasis_a_single-center_experience_of_11_years_in_Tianjin_China/6680259 抽象背景骨肉瘤是最常见的原发性恶性骨肿瘤。当前的研究来描述原发性骨肉瘤患者的一般情况一个癌症中心在天津,中国和探讨骨肉瘤肺转移患者的相关因素。方法2009年2月到2020年10月,来自天津医科大学癌症研究所和医院的病人进行回顾性分析。kaplan meier方法被用来评估骨肉瘤患者的总生存期。Cox比例风险进行回归分析来分析所有骨肉瘤患者的预后因素与肺转移患者,分别。此外,发展中肺转移的危险因素中确定同步肺转移(SLM)以及异时肺转移(传销)的病人。结果共有203名患者参与其中,150名患者被成功随访生存状态。骨肉瘤的5年生存率是70.0%,患者生存数月SLM和传销是33.3±12.6,45.8±7.4个月,分别。肺转移的存在是骨肉瘤的预后生存的独立预后因素。肺转移,患者21例(10.3%)显示肺转移的诊断骨肉瘤67(33%)术后期间被诊断为肺转移。 T3 stage (OR = 11.415, 95%CI 1.362–95.677, P = 0.025) and bone metastasis (OR = 6.437, 95%CI 1.69–24.51, P = 0.006) were risk factors of SLM occurrence. Bone metastasis (OR = 1.842, 95%CI 1.053–3.224, P = 0.032), good necrosis (≥ 90%, OR = 0.032, 95%CI 0.050–0.412, P < 0.001), elevated Ki-67 (OR = 2.958, 95%CI 1.098–7.969, P = 0.032) and elevated LDH (OR = 1.791, 95%CI 1.020–3.146, P = 0.043) were proved to be independent risk factors for developing MLM. Conclusion The overall survival, prognostic factors and risk factors for lung metastasis in this single center provided insight about osteosarcoma management. 医学、细胞生物学、生物技术、发育生物学、癌症、科学政策、植物生物学,生物科学不是其他地方分类 妈,05年6月2023 03:08:14 GMT //www.veemusicshop.com/collections/Identification_of_proteins_regulated_by_chlorogenic_acid_in_an_ischemic_animal_model_a_proteomic_approach/6680269//www.veemusicshop.com/collections/Identification_of_proteins_regulated_by_chlorogenic_acid_in_an_ischemic_animal_model_a_proteomic_approach/6680269 抽象背景脑缺血是一种严重的神经系统疾病,可导致高发病率和死亡率。绿原酸是一种多酚化合物具有抗氧化,可以调节蛋白在脑缺血。大脑中动脉闭塞(MCAO)手术诱导缺血性脑损伤,并保持24小时。绿原酸(30毫克/公斤)或车辆管理进入腹膜腔2 h MCAO后手术。大脑皮层组织收集进一步的研究和蛋白质组学方法进行识别的蛋白质改变了绿原酸在MCAO的动物。结果我们发现,绿原酸缓解在adenosylhomocysteinase变化,glycerol-3-phosphate脱氢酶,真核翻译起始因子4 a-ii,载脂蛋白-ⅰ,mu-crystallin。这些蛋白质在MCAO动物车辆减少,这些削减被绿原酸减毒治疗。减少的缓解绿原酸是由反转录PCR证实的技术。这些蛋白质与能量代谢、蛋白质合成、炎症和生理代谢。他们是绿原酸的参与神经保护作用。 These results showed that chlorogenic acid alleviates the neurological disorders caused by MCAO and regulates the expression of proteins involved in neuroprotection. Conclusions Therefore, our findings provide evidence that chlorogenic acid plays a neuroprotective role in stroke animal models by controlling specific proteins. 生物化学、医学、细胞生物学、分子生物学、神经科学、生理学、药理学、免疫学、精神卫生、化学科学不是其他国家机密 妈,05年6月2023 03:08:14 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_3_of_Incidence_survival_and_associated_factors_estimation_in_osteosarcoma_patients_with_lung_metastasis_a_single-center_experience_of_11_years_in_Tianjin_China/23293323//www.veemusicshop.com/articles/journal_contribution/Additional_file_3_of_Incidence_survival_and_associated_factors_estimation_in_osteosarcoma_patients_with_lung_metastasis_a_single-center_experience_of_11_years_in_Tianjin_China/23293323 其他文件3:补充表3。骨肉瘤病人肺metastasectomy的详细信息。 医学、细胞生物学、生物技术、发育生物学、癌症、科学政策、植物生物学,生物科学不是其他地方分类 妈,05年6月2023 03:08:13 GMT //www.veemusicshop.com/articles/figure/Additional_file_1_of_Identification_of_proteins_regulated_by_chlorogenic_acid_in_an_ischemic_animal_model_a_proteomic_approach/23293324//www.veemusicshop.com/articles/figure/Additional_file_1_of_Identification_of_proteins_regulated_by_chlorogenic_acid_in_an_ischemic_animal_model_a_proteomic_approach/23293324 欧宝app苹果下载软件额外的文件1。绿原酸变弱的增加由于MCAO氧化应激损伤。活性氧在大脑皮层和脂质过氧化作用分析车辆+骗局,绿原酸+骗局,汽车+大脑中动脉闭塞,海巡署+ MCAO的动物。MCAO伤害增加2′7′必经dichlorofluoresceinand malondialdehydelevels,这些增加了绿原酸变弱。Dataare表示为均值±S.E.M.# p < 0.01与车辆+虚假的动物,* p < 0.05与车辆+ MCAO的动物。 生物化学、医学、细胞生物学、分子生物学、神经科学、生理学、药理学、免疫学、精神卫生、化学科学不是其他国家机密 妈,05年6月2023 03:08:13 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_2_of_Incidence_survival_and_associated_factors_estimation_in_osteosarcoma_patients_with_lung_metastasis_a_single-center_experience_of_11_years_in_Tianjin_China/23293320//www.veemusicshop.com/articles/journal_contribution/Additional_file_2_of_Incidence_survival_and_associated_factors_estimation_in_osteosarcoma_patients_with_lung_metastasis_a_single-center_experience_of_11_years_in_Tianjin_China/23293320 欧宝app苹果下载软件额外的文件2:补充表2。识别骨肉瘤肺转移患者的预后因素(N = 50)。 医学、细胞生物学、生物技术、发育生物学、癌症、科学政策、植物生物学,生物科学不是其他地方分类 妈,05年6月2023 03:08:11 GMT //www.veemusicshop.com/collections/PEGylated_magnetic_nanographene_oxide_for_targeted_delivery_of_arsenic_trioxide_and_sec-o-glucosylhamaudol_in_tumor_treatment_with_improved_dual-drugs_synergistic_effect/6680257//www.veemusicshop.com/collections/PEGylated_magnetic_nanographene_oxide_for_targeted_delivery_of_arsenic_trioxide_and_sec-o-glucosylhamaudol_in_tumor_treatment_with_improved_dual-drugs_synergistic_effect/6680257 抽象的三氧化二砷(ATO)是一个有前途的化学治疗剂,但其临床应用是有限的由于其药物动力学和dose-limited毒性。此外,ATO的组合和sec-o-glucosylhamaudol (SOG)可以提高肝癌的治疗效果。在这项研究中,聚乙二醇氧化磁nanographene (PEG@MGO)用作磁性载体提高靶向药物输送系统的能力。ATO装载和SOG PEG@MGO纳米粒子表面通过静电相互作用。pH敏感性,这可以使纳米复合材料的生物相容性显示磁化率和高承载能力的药物。人类肝癌细胞系的体外细胞毒性研究(HepG2)细胞表现出更大的细胞毒性和ATO之间明显的协同效应,SOG比单一药物通过MTT测定纳米颗粒。体外细胞摄取被普鲁士蓝染色观察荧光标记。结果表明PEG@MGO细胞内化率高。ATO和SOG同行并装、显著抑制体内肿瘤的生长,这可能是由于氧化应激和proapoptotic效果。这种类型的癌症治疗的耐多药纳米复合材料提供了一个不错的选择。 Graphical Abstract A pH-sensitive polyethylene glycol-modified magnetic graphene oxide loaded with ATO and SOG (PEG@MGO@ATO + SOG) was prepared for the magnetically targeted and efficient synergistic-chemo cancer therapy, which exhibited high specificity and good biocompatibility. 生物化学、医学、细胞生物学、药理学、生物技术、癌症、空间科学,化学科学分类 妈,05年6月2023 03:08:09 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Incidence_survival_and_associated_factors_estimation_in_osteosarcoma_patients_with_lung_metastasis_a_single-center_experience_of_11_years_in_Tianjin_China/23293317//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Incidence_survival_and_associated_factors_estimation_in_osteosarcoma_patients_with_lung_metastasis_a_single-center_experience_of_11_years_in_Tianjin_China/23293317 欧宝app苹果下载软件额外的文件1:补充表1。T的定义阶段和N阶段患者的骨肉瘤。 医学、细胞生物学、生物技术、发育生物学、癌症、科学政策、植物生物学,生物科学不是其他地方分类 妈,05年6月2023 03:08:09 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_PEGylated_magnetic_nanographene_oxide_for_targeted_delivery_of_arsenic_trioxide_and_sec-o-glucosylhamaudol_in_tumor_treatment_with_improved_dual-drugs_synergistic_effect/23293315//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_PEGylated_magnetic_nanographene_oxide_for_targeted_delivery_of_arsenic_trioxide_and_sec-o-glucosylhamaudol_in_tumor_treatment_with_improved_dual-drugs_synergistic_effect/23293315 欧宝app苹果下载软件额外的文件1:图S1。DLS Fe3O4纳米粒子的结果。图。S2。TEM图像的Fe3O4纳米颗粒,无花果。S3。PEG@MGO分散在水中的照片。答:PEG@MGO存储超过25℃/ 60% rh 30天;b . PEG@MGO存储超过40℃/ 75% 30天。无花果。S4。HepG2的抑制率在不同浓度组合的ATO和SOG后48 h共培养。 Fig S5. H&E histology images of the major organs in mice after administration of (A) PBS, (B) Magnet+PEG@MGO@ATO+SOG, (C) ATO, (D) Magnet+PEG@MGO@ATO for 18 days. 生物化学、医学、细胞生物学、药理学、生物技术、癌症、空间科学,化学科学分类 妈,05年6月2023 03:08:08 GMT //www.veemusicshop.com/articles/dataset/Nanowire-based_smart_windows_combining_electro-_and_thermochromic_for_dynamic_regulation_of_solar_radiation/22650709//www.veemusicshop.com/articles/dataset/Nanowire-based_smart_windows_combining_electro-_and_thermochromic_for_dynamic_regulation_of_solar_radiation/22650709 1。数据包含每一个手稿图,每一个人物支持信息。2。透射电子显微镜(TEM)图像获得使用日立h - 7700透射电子显微镜在加速电压100 kV。扫描电子显微镜(SEM)图像是由场发射扫描电子显微分析仪(蔡司上40扫描电子显微镜的加速电压5 kV)。X射线衍射(XRD)测量模式在飞利浦X ' Pert Pro超级X射线衍射仪配备graphite-monochromatized铜基米-雷克南辐射。在DSC差示扫描量热法曲线记录Q2000 (TA)工具。UV-VIS-NIR光谱被记录在solidspec - 3700(日本岛津公司公司)在透射模式与积分球在室温和配备TS120加热和冷却阶段(武汉Congtical技术公司)。霾光谱测量的cs - 700阴霾计(杭州CHNSpec技术)的波长范围400 - 760 nm。icp - aes数据获得的最适条件7300 DV仪器(PerkinElmer公司)。 The sheet resistance of the film was tested by M-3 portable four-point probe test meter (Suzhou lattice electron Limited company). The mechanical stability of the devices was tested by a mechanical system (Instron 5565A). All the electrochemical measurements were carried out using a three-electrode configuration with a Pt wire as the counter electrode and Ag/AgCl as the reference electrode on a CHI760D electrochemistry workstation without separate instructions. The time-dependent infrared images were recorded by Thermal imager VarioCAM hr head 680 (InfraTec GmbH). 3.The model chamber was built using recycled carton external structure brackets and wrapped with aluminum foil for thermal insulation on the outside the dimensions of the model chamber are 15 × 10 × 10 cm3. 4.The software of EnergyPlus was used to evaluate the energy consumption with different windows in different climate zones. 无机化学、纳米化学方面和超分子化学、光学性质的材料 太阳,04年6月2023 07:01:25 GMT //www.veemusicshop.com/articles/dataset/Extreme_Atmospheric_Rivers_in_a_Warming_Climate/22631143//www.veemusicshop.com/articles/dataset/Extreme_Atmospheric_Rivers_in_a_Warming_Climate/22631143 图1是观察和模拟的耳朵。图2是耳朵应对人力资源CESM人为气候变暖。图3是耳朵应对变暖水平不同。图4是耳朵登陆我国应对人力资源CESM人为气候变暖。图5是耳朵和ECs之间耦合关系。图S1是观察和模拟耳强度和发生频率。图S2 HighResMIP模拟的耳朵。图S3是比较模拟耳朵人力资源和LR CESM之间。图S4是耳朵的敏感性预测人力资源CESM ARDTs。图S5是耳朵热力学和动态响应inHR CESM。 Figure S6 is landfalling EAR responses at different stages in HR CESM. Figure S7 is sensitivity of EAR projections to IVT thresholds used to define EARs in HR CESM. Table S1 is the percentage of EARs pairing with ECs in HR CESM. 水文、气候变化过程 太阳,04年6月2023 07:01:18 GMT //www.veemusicshop.com/collections/The_impact_of_different_care_dependencies_on_people_s_willingness_to_provide_informal_care_a_discrete_choice_experiment_in_Germany/6679836//www.veemusicshop.com/collections/The_impact_of_different_care_dependencies_on_people_s_willingness_to_provide_informal_care_a_discrete_choice_experiment_in_Germany/6679836 提供的抽象背景非正式护理家庭成员,朋友或邻居是一个主要的支柱在德国长期护理系统。随着care-dependent老年人数量的增长,确保他们未来护理仍然依赖于家庭成员的意愿,朋友或邻居认为非正式照顾者的角色。本研究旨在探讨影响人民的意愿与主要近亲属提供非正式护理认知相比物理损伤。方法分配给一个在线调查大众在德国,这导致了260名参与者。创建一个离散选择试验引起和量化人们的喜好。一个条件logit模型被用来研究偏好和边际愿意接受值估计一个小时的非正式的护理。结果每天增加护理时间(小时)和预期持续时间照料家庭的负面价值的参与者和减少护理意愿。描述两个护理依赖的参与者的决策产生重大影响。必须提供保健认知障碍的患者近亲略优于照顾相对与物理损伤。结论我们的研究结果显示不同的影响因素对愿意提供非正式的近亲。 How far the preference weights as well as the high willingness-to-accept values for an hour of caregiving can be explained by the sociodemographic structure of our cohort needs to be investigated by further research. Participants slightly preferred caring for a close relative with cognitive impairments, which might be explained by fear or discomfort with providing personal care to a relative with physical impairments or feelings of sympathy and pity towards people with dementia. Future qualitative research designs can help understand these motivations. 生物科学社会学、科学政策、传染病、没有其他机密 太阳,04年6月2023 03:13:05 GMT //www.veemusicshop.com/collections/Prophylactic_drainage_versus_non-drainage_following_gastric_cancer_surgery_a_meta-analysis_of_randomized_controlled_trials_and_observational_studies/6679838//www.veemusicshop.com/collections/Prophylactic_drainage_versus_non-drainage_following_gastric_cancer_surgery_a_meta-analysis_of_randomized_controlled_trials_and_observational_studies/6679838 抽象背景的作用预防排水(PD)在胃癌胃切除术(GC)是不完善的。本研究的目的是比较之间的围手术期结果PD和non-drainage (ND) GC接受胃切除术的患者。方法系统回顾电子数据库包括PubMed、Embase,网络科学,Cochrane图书馆、中国国家知识基础设施进行到2022年12月。所有符合条件的随机对照试验(相关的)和观察性研究包括meta-analyzed分开。这个协议是普洛斯彼罗的注册号CRD42022371102。结果总的来说,7相关(783名患者)和14个观察性研究(4359名患者)是最终包括在内。相关数据表明,患者在ND组总并发症率较低(OR = 0.68;95%置信区间:0.47—-0.98;P = 0.04;I2 = 0%),更早的时间软饮食(MD =−0.27; 95%CI: − 0.55 to 0.00; P = 0.05; I2 = 0%) and shorter length of hospital stay (MD =  − 0.98; 95%CI: − 1.71 to − 0.26; P = 0.007; I2 = 40%). While other outcomes including anastomotic leakage, duodenal stump leakage, pancreatic leakage, intra-abdominal abscess, surgical-site infection, pulmonary infection, need for additional drainage, reoperation rate, readmission rate, and mortality were not significantly different between the two groups. Meta-analyses on observational studies showed good agreement with the pooled results from RCTs, with higher statistical power. Conclusion The present meta-analysis suggests that routine use of PD may not be necessary and even harmful in GC patients following gastrectomy. However, well-designed RCTs with risk-stratified randomization are still needed to validate the results of our study. 医学、科技政策、环境科学不是其他国家机密 太阳,04年6月2023 03:13:05 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Prophylactic_drainage_versus_non-drainage_following_gastric_cancer_surgery_a_meta-analysis_of_randomized_controlled_trials_and_observational_studies/23292143//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Prophylactic_drainage_versus_non-drainage_following_gastric_cancer_surgery_a_meta-analysis_of_randomized_controlled_trials_and_observational_studies/23292143 欧宝app苹果下载软件额外的文件1:表S1。每个数据库的详细搜索策略。表S2。多元回归分析的结果。图S1。森林的围手术期的结果包括:a .脓疡;b .十二指肠残漏;c .胰漏;d .腹腔脓肿;大肠手术部位感染; F. Pulmonary infection; G. Mortality; H. Need for additional drainage; I. Readmission; J. Reoperation. Figure S2. Subgroup analyses of perioperative outcomes based on sample size (≥100 vs. <100). A. total complications; B. anastomotic leakage; C. Duodenal stump leakage; D. Pancreatic leakage; E. Intra-abdominal abscess; F. Surgical-site infection; G. Pulmonary infection; H. Mortality; I. Time to first soft diet; J. Length of hospital stay; K. Need for additional drainage; L. Readmission; M. Reoperation. Figure S3. Subgroup analyses of perioperative outcomes based on academic institution (Yes vs. No). A. total complications; B. anastomotic leakage; C. Duodenal stump leakage; D. Pancreatic leakage; E. Intra-abdominal abscess; F. Surgical-site infection; G. Pulmonary infection; H. Mortality; I. Time to first soft diet; J. Length of hospital stay; K. Need for additional drainage; L. Readmission; M. Reoperation. Figure S4. Subgroup analyses of perioperative outcomes in GC patients who underwent laparoscopic surgery. A. total complications; B. anastomotic leakage; C. Duodenal stump leakage; D. Pancreatic leakage; E. Intra-abdominal abscess; F. Surgical-site infection; G. Pulmonary infection; H. Time to first soft diet; I. Length of hospital stay; J. Reoperation. Figure S5. Subgroup analyses of perioperative outcomes in GC patients who underwent total gastrectomy. A. total complications; B. anastomotic leakage; C. Duodenal stump leakage; D. Pancreatic leakage; E. Intra-abdominal abscess; F. Surgical-site infection; G. Pulmonary infection; H. Mortality; I. Time to first soft diet; J. Length of hospital stay; K. Need for additional drainage; L. Readmission; M. Reoperation. Figure S6. Begg’s funnel plot of perioperative outcomes including: A. total complications; B. anastomotic leakage; C. Intra-abdominal abscess; D. Surgical-site infection; E. Pulmonary infection; F. Time to first soft diet; G. Length of hospital stay. All P values >0.05. 医学、科技政策、环境科学不是其他国家机密 太阳,04年6月2023 03:13:05 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_The_impact_of_different_care_dependencies_on_people_s_willingness_to_provide_informal_care_a_discrete_choice_experiment_in_Germany/23292141//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_The_impact_of_different_care_dependencies_on_people_s_willingness_to_provide_informal_care_a_discrete_choice_experiment_in_Germany/23292141 补充材料1 生物科学社会学、科学政策、传染病、没有其他机密 太阳,04年6月2023 03:13:04 GMT //www.veemusicshop.com/collections/Clinical_application_of_next_generation_sequencing-based_haplotype_linkage_analysis_in_the_preimplantation_genetic_testing_for_germline_mosaicisms/6679833//www.veemusicshop.com/collections/Clinical_application_of_next_generation_sequencing-based_haplotype_linkage_analysis_in_the_preimplantation_genetic_testing_for_germline_mosaicisms/6679833 抽象背景胚胎植入前的基因检测(页面表)单基因疾病(PGT-M)生殖系镶嵌现象以前高度依赖聚合酶链反应(PCR)的定向突变检测结合连锁分析短串联重复序列(str)。然而,str的数量通常是有限的。此外,设计合适的探针和优化复合PCR反应条件是耗时和费力。在这里,我们评估的有效性下一代测序(门店)的单体型连锁分析页面表生殖系镶嵌性。方法PGT-M NGS-based单体型进行了链接的分析两个家庭与母性生殖系镶嵌性的x染色体的杜氏肌肉营养不良症(DMD)突变(del 45 ~ 50)外显子或常染色体TSC1突变(c.2074C > T)。滋养外胚层活检和多个位移放大(MDA)进行了总共9个胚泡。门店和桑格测序的基因组DNA进行家庭成员和胚胎MDA产品检测DMD删除和TSC1突变,分别。单核苷酸多态性(SNP)与门店网站发现了致病突变密切相关并在单体型连锁分析。NGS-based筛查非整倍性进行所有胚胎减少怀孕的风险损失。九种胚细胞结果显示的页面表结果。 Each family underwent one or two frozen-thawed embryo transfer cycles to obtain a clinical pregnancy, and the prenatal diagnosis showed that the fetus was genotypically normal and euploid for both families. Conclusions NGS-SNP could effectively realize PGT for germline mosaicism. Compared with PCR-based methods, the NGS-SNP method with increased polymorphic informative markers can achieve a greater diagnostic accuracy. Further studies are warranted to verify the effectiveness of NGS-based PGT of germline mosaicism cases in the absence of surviving offsprings. 遗传学 太阳,04年6月2023 03:13:02 GMT //www.veemusicshop.com/collections/Cross-sectional_analysis_characterizing_the_use_of_rank_preserving_structural_failure_time_in_oncology_studies_changes_to_hazard_ratio_and_frequency_of_inappropriate_use/6679835//www.veemusicshop.com/collections/Cross-sectional_analysis_characterizing_the_use_of_rank_preserving_structural_failure_time_in_oncology_studies_changes_to_hazard_ratio_and_frequency_of_inappropriate_use/6679835 抽象背景等级保护结构失效时间(RPSFT)的统计方法来纠正或调整交叉在临床试验中,通过估算反事实的影响总生存期(OS)当控制臂的病人不接受介入药物当他们的肿瘤进展。我们试图研究相关性的强度差异矫正和纠正操作系统风险比率,比例的交叉,和描述实例的基本和连续的功效。方法在横断面分析(2003 - 2023),我们回顾了肿瘤学的随机试验,RPSFT分析调整操作系统风险比用于抗癌药物的病人了。我们计算的百分比RPSFT研究评估基本功效的药物(有或没有一个标准的护理(SOC))或连续效力和操作系统之间的相关性风险比差异(未调整和调整)和交叉的百分比。结果在65年的研究中,中值差异的和纠正操作系统风险比−0.1(四分位数1、四分位数3:−0.3−0.06)。交叉的平均比例为56%(四分位数1,第三四分位数:37%至72%)。所有的研究都是由行业或有作者的员工。12(19%)测试药物的研究基本没有SOC时功效;34(52%)测试药物的研究已经有一个SOC时基本功效;19(29%)的研究测试了药物的顺序功效。 The correlation between the uncorrected and corrected OS hazard ratio difference and the percentage of crossover was 0.44 (95% CI: 0.21 to 0.63). Conclusions RPSFT is a common tactic used by the industry to reinterpret trial results. Nineteen percent of RPSFT use is appropriate. We recognize that while crossover can bias OS results, the allowance and handling of crossover in trials should be limited to appropriate circumstances. 医学、生物技术、癌症、科学政策 太阳,04年6月2023 03:13:02 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Clinical_application_of_next_generation_sequencing-based_haplotype_linkage_analysis_in_the_preimplantation_genetic_testing_for_germline_mosaicisms/23292138//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Clinical_application_of_next_generation_sequencing-based_haplotype_linkage_analysis_in_the_preimplantation_genetic_testing_for_germline_mosaicisms/23292138 欧宝app苹果下载软件额外的文件1:下一代sequencing-based demand media突变检测的结果为家庭1。 遗传学 太阳,04年6月2023 03:13:02 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Cross-sectional_analysis_characterizing_the_use_of_rank_preserving_structural_failure_time_in_oncology_studies_changes_to_hazard_ratio_and_frequency_of_inappropriate_use/23292140//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Cross-sectional_analysis_characterizing_the_use_of_rank_preserving_structural_failure_time_in_oncology_studies_changes_to_hazard_ratio_and_frequency_of_inappropriate_use/23292140 欧宝app苹果下载软件额外的文件1:补充图1。线性回归诊断情节肿瘤学研究报告等级保护结构失效时间。所有的研究。B)与一个离群值删除。补充图2。鉴定等级保护结构失效时间在肿瘤试验分析。 医学、生物技术、癌症、科学政策 太阳,04年6月2023 03:13:02 GMT //www.veemusicshop.com/collections/Structural_modification_of_resveratrol_analogue_exhibits_anticancer_activity_against_lung_cancer_stem_cells_via_suppression_of_Akt_signaling_pathway/6679824//www.veemusicshop.com/collections/Structural_modification_of_resveratrol_analogue_exhibits_anticancer_activity_against_lung_cancer_stem_cells_via_suppression_of_Akt_signaling_pathway/6679824 抽象背景化合物与癌症干细胞(CSC)抑制活动承诺改善肺癌的临床结果。为了实现这个目标,我们发现白藜芦醇的CSC-targeting活动(RES)模拟moscatilin (MOS)。在RES轻微的结构修改,金属氧化物半导体显示主要的细胞毒性和CSC-suppressive效果。方法三个人类肺癌细胞系,即H23 H292, A549,被用来比较RES和MOS的影响。细胞生存能力和MTT测定细胞凋亡测定和Hoechst33342 / PI双染色。Anti-proliferative活动是由集落形成试验和细胞周期分析。细胞内活性氧(ROS)是通过测量荧光显微镜使用DCFH2-DA染色。生成CSC-rich A549细胞的数量,和CSC标记,一种蛋白激酶信号测定免疫印迹和免疫荧光分析。分子对接和分子动力学(MD)模拟被用来预测化合物的可能绑定Akt蛋白。结果在这项研究中,我们评估了RES和MOS对肺癌的影响及其anti-CSC潜力。 Compared with RES, its analog MOS more effectively inhibited cell viability, colony formation, and induced apoptosis in all lung cancer cell lines (H23, H292, and A549). We further investigated the anti-CSC effects on A549 CSC-rich populations and cancer adherent cells (A549 and H23). MOS possesses the ability to suppress CSC-like phenotype of lung cancer cells more potent than RES. Both MOS and RES repressed lung CSCs by inhibiting the viability, proliferation, and lung CSC-related marker CD133. However, only MOS inhibits the CSC marker CD133 in both CSC-rich population and adherent cells. Mechanistically, MOS exerted its anti-CSC effects by inhibiting Akt and consequently restored the activation of glycogen synthase kinase 3β (GSK-3β) and decreased the pluripotent transcription factors (Sox2 and c-Myc). Thus, MOS inhibits CSC-like properties through the repression of the Akt/GSK-3β/c-Myc pathway. Moreover, the superior inhibitory effects of MOS compared to RES were associated with the improved activation of various mechanism, such as cell cycle arrest at G2/M phase, production of ROS-mediated apoptosis, and inhibition of Akt activation. Notably, the computational analysis confirmed the strong interaction between MOS and Akt protein. MD simulations revealed that the binding between MOS and Akt1 was more stable than RES, with MM/GBSA binding free energy of − 32.8245 kcal/mol at its allosteric site. In addition, MOS interacts with Trp80 and Tyr272, which was a key residue in allosteric inhibitor binding and can potentially alter Akt activity. Conclusions Knowledge about the effect of MOS as a CSC-targeting compound and its interaction with Akt is important for the development of drugs for the treatment of CSC-driven cancer including lung cancer. 生物物理学、生物化学、医学、细胞生物学、分子生物学、药理学、发育生物学、癌症、血液学、化学科学不是其他国家机密 太阳,04年6月2023 03:12:59 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Structural_modification_of_resveratrol_analogue_exhibits_anticancer_activity_against_lung_cancer_stem_cells_via_suppression_of_Akt_signaling_pathway/23292135//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Structural_modification_of_resveratrol_analogue_exhibits_anticancer_activity_against_lung_cancer_stem_cells_via_suppression_of_Akt_signaling_pathway/23292135 欧宝app苹果下载软件额外的文件1 生物物理学、生物化学、医学、细胞生物学、分子生物学、药理学、发育生物学、癌症、血液学、化学科学不是其他国家机密 太阳,04年6月2023 03:12:58 GMT //www.veemusicshop.com/collections/Flexible_hidden_Markov_models_for_behaviour-dependent_habitat_selection/6679823//www.veemusicshop.com/collections/Flexible_hidden_Markov_models_for_behaviour-dependent_habitat_selection/6679823 抽象的背景有强烈的动机模型behaviour-dependent栖息地的选择,因为这可以帮助描述关键栖息地重要生命过程和减少模型参数的偏差。为了这个目的,一个两级建模方法往往是采取:(i)分类行为的隐马尔科夫模型(HMM)和(2)一个步骤选择函数(SSF)每个子集的数据。然而,这种方法并不正确地考虑行为分类的不确定性,也不允许各州取决于栖息地选择。另一种方法是估计状态切换和栖息地选择在一个叫做HMM-SSF集成模型。方法建立在最近的工作方法,使HMM-SSF方法更有效和通用。我们专注于写作的模型作为一个嗯观测过程被定义为一个社保基金,这样著名的推论方法摘要可直接用于参数估计和状态的分类。我们协变量对模型进行扩展,以包括嗯跃迁概率,允许推论的时间和细化司机状态切换。我们将演示的方法通过一个说明性的例子平原斑马(科仕斑驴),包括状态估计和模拟估计利用分布。斑马的结果分析,我们发现两种行为状态,分明的运动模式和栖息地选择(“扎营”和“探索性”)。特别是,尽管斑马更倾向于高草原行为州地区,这个选择更强的快,指导勘探状态。 We also found a clear diel cycle in behaviour, which indicated that zebras were more likely to be exploring in the morning and encamped in the evening. Conclusions This method can be used to analyse behaviour-specific habitat selection in a wide range of species and systems. A large suite of statistical extensions and tools developed for HMMs and SSFs can be applied directly to this integrated model, making it a very versatile framework to jointly learn about animal behaviour, habitat selection, and space use. 统计数据 太阳,04年6月2023 03:12:57 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Flexible_hidden_Markov_models_for_behaviour-dependent_habitat_selection/23292134//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Flexible_hidden_Markov_models_for_behaviour-dependent_habitat_selection/23292134 欧宝app苹果下载软件额外的文件1。附录的协变量解释运动的推导伽马分布的步骤和•冯•米塞斯的转向角度。附录B包含一个模拟研究来验证提出的实现方法的主要文本的手稿。所有的代码可在Zenodo和GitHub。 统计数据 太阳,04年6月2023 03:12:56 GMT //www.veemusicshop.com/collections/Increased_levels_of_PD1_and_glycolysis_in_CD4_T_cells_are_positively_associated_with_lymph_node_metastasis_in_OSCC/6679818//www.veemusicshop.com/collections/Increased_levels_of_PD1_and_glycolysis_in_CD4_T_cells_are_positively_associated_with_lymph_node_metastasis_in_OSCC/6679818 抽象背景颈部淋巴结转移是最贫穷的预后因素之一在口腔鳞状细胞癌(OSCC)。激活免疫细胞通常有代谢异常在肿瘤微环境。然而,它是未知的异常糖酵解T细胞能否促进转移性淋巴结在OSCC患者。本研究的目的是研究免疫检查站转移性淋巴结的影响并确定糖酵解和免疫检查点之间的关系表达CD4 + T细胞。方法流式细胞仪和免疫荧光染色法被用来分析CD4 + PD1 + T细胞之间的差异转移性淋巴结(LN +)和消极的淋巴结(LN−)。rt - pcr进行细节的表达免疫检查点和LN +和LN−glycolysis-related酶。结果的频率在LN + CD4 + T细胞减少患者(p = 0.0019)。PD1表达式LN +显著增加比LN−(p = 0.0205)。同样,PD1 CD4 + T细胞在LN +的LN−相比显著增加。此外,glycolysis-related酶水平从LN + CD4 + T细胞在LN患者显著高于−病人。 PD1 and Hk2 expression in CD4+ T cells was also increased in LN+ OSCC patients with prior surgical treatment compared to those without. Conclusions These findings suggest that lymph node metastasis and recurrence in OSCC are associated with increases in PD1 and glycolysis in CD4+ T cells; this response may serve as a potential regulator of OSCC progression. 免疫学 太阳,04年6月2023 03:12:55 GMT //www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Increased_levels_of_PD1_and_glycolysis_in_CD4_T_cells_are_positively_associated_with_lymph_node_metastasis_in_OSCC/23292132//www.veemusicshop.com/articles/journal_contribution/Additional_file_1_of_Increased_levels_of_PD1_and_glycolysis_in_CD4_T_cells_are_positively_associated_with_lymph_node_metastasis_in_OSCC/23292132 补充材料1 免疫学 太阳,04年6月2023 03:12:55 GMT //www.veemusicshop.com/collections/Prevalence_of_different_virulence_factors_and_their_association_with_antimicrobial_resistance_among_Pseudomonas_aeruginosa_clinical_isolates_from_Egypt/6679808//www.veemusicshop.com/collections/Prevalence_of_different_virulence_factors_and_their_association_with_antimicrobial_resistance_among_Pseudomonas_aeruginosa_clinical_isolates_from_Egypt/6679808 抽象的背景出现多重耐药铜绿假单胞菌,再加上病原体的毒性的因素,导致高发病率和死亡率。目前的研究调查潜在的协会之间的抗生素耐药性和毒力因素的生产在铜绿假单胞菌临床分离株主要来自亚历山大大学医院在埃及。我们也评估表型检测毒性的潜力因素反映毒性检测毒性基因的存在。海藻酸的作用在生物膜的形成和ambroxol的影响,黏液溶解的代理,抑制生物膜的形成。结果发现耐多药表型之间的隔离的79.8%。最主要的毒性的因素是生物膜的形成(89.4%),而DNase至少发现(10.6%)。颜料生产与头孢他啶敏感性显著相关,磷脂酶C生产明显对头孢吡肟的敏感性有关,和DNase生产与中间meropenem阻力显著相关。测试中毒性基因,lasB algD显示,患病率最高(分别为93.3%和91.3%),而toxA和plcN发现最小的(分别为46.2%和53.8%)。重大协会toxA与头孢他啶敏感性,与头孢他啶和aztreonam易感性挂式,plcH观察piperacillin-tazobactam易感性。有显著相关性碱性蛋白酶生产和检测algD, lasB,挂式,plcH plcN; pigment production and the presence of algD, lasB, toxA and exoS; and gelatinase production and the existence of lasB, exoS and plcH. Ambroxol showed a high anti-biofilm activity (5% to 92%). Quantitative reverse transcriptase polymerase chain reaction showed that alginate was not an essential matrix component in P. aeruginosa biofilms. Conclusions High virulence coupled with the isolates’ multi-drug resistance to commonly used antimicrobials would increase morbidity and mortality rates among P. aeruginosa infections. Ambroxol that displayed anti-biofilm action could be suggested as an alternative treatment option, yet in vivo studies are required to confirm these findings. We recommend active surveillance of antimicrobial resistance and virulence determinant prevalence for better understanding of coregulatory mechanisms. 生物化学、医学、微生物学、生物技术、生态学、免疫学、癌症、传染病、病毒学、生物科学而不是其他地方分类 太阳,04年6月2023 03:12:53 GMT //www.veemusicshop.com/collections/Selenoproteins_synergistically_protect_porcine_skeletal_muscle_from_oxidative_damage_via_relieving_mitochondrial_dysfunction_and_endoplasmic_reticulum_stress/6679812//www.veemusicshop.com/collections/Selenoproteins_synergistically_protect_porcine_skeletal_muscle_from_oxidative_damage_via_relieving_mitochondrial_dysfunction_and_endoplasmic_reticulum_stress/6679812 抽象背景猪骨骼肌是容易受到氧化损伤,导致生长迟缓。硒蛋白对动物抗氧化系统的重要组成部分,一般由膳食硒(Se)监管的水平。这里,我们开发了饮食氧化应激(DOS)诱导猪模型探讨硒蛋白的保护作用DOS-induced骨骼肌生长迟缓。结果膳食氧化应激引起的猪骨骼肌氧化损伤和生长迟缓,这是伴随着线粒体功能障碍,内质网(ER)压力,蛋白质和脂质代谢紊乱。补充Se(0.3、0.6或0.9毫克Se /公斤)形式的羟基硒代蛋氨酸(OH-SeMet)线性增加肌肉Se沉积和表现出保护作用通过调节selenotranscriptome和关键硒蛋白的表达,主要是反映在ROS水平较低和高在骨骼肌抗氧化能力和线粒体功能障碍的缓解和ER应激。更重要的是,硒蛋白抑制DOS诱导蛋白质和脂质退化和提高蛋白质和脂类生物合成通过调节AKT / mTOR / S6K1和AMPK / SREBP-1信号通路在骨骼肌。然而,一些参数如氧化酶的活性和T-SOD JNK2的蛋白质丰富,CLPP, SELENOS SELENOF没有显示存在剂量依赖的相关性变化。值得注意的是,几个关键的硒蛋白,如MSRB1 SELENOW, SELENOM, SELENON SELENOS扮演独特的角色在这个保护。结论硒蛋白的表达增加了膳食OH-SeMet可以减轻线粒体功能异常和ER应激,协同恢复蛋白质和脂类的生物合成,从而减轻骨骼肌生长迟缓。我们的研究提供了这些预防措施在畜牧业骨骼肌发育迟缓。 Biochemistry, Medicine, Cell Biology, Genetics, Physiology, Inorganic Chemistry, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified 太阳,04年6月2023 03:12:51 GMT

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